HKEY_CURRENT_USER\Control Panel\Mouse allows to change the behavior of the mouse (aka pointer). reg add "HKEY_CURRENT_USER\Control Panel\Mouse" /t REG_SZ /v MouseSensitivity /d "10" /f
(get-itemProperty 'HKCU:\Control Panel\Mouse' ).MouseSensitivity set-itemProperty 'HKCU:\Control Panel\Mouse' -name MouseSensitivity -value 20
SendMessage(HWND_BROADCAST, WM_SETTINGCHANGE, 0, "Environment") should be executed in order for the changes to take effect. WheelScrollLines under HKEY_CURRENT_USER\Control Panel\Desktop.